IMPROVED IN VITRO MODEL FOR INTRANASAL MUCOSAL DRUG DELIVERY: PRIMARY OLFACTORY AND RESPIRATORY EPITHELIAL CELLS COMPARED WITH THE PERMANENT NASAL CELL LINE RPMI 2650

Background: The epithelial layer of the nasal mucosa is the first barrier for drug permeation during intranasal VIT K drug delivery.With increasing interest for intranasal pathways, adequate in vitro models are required.Here, porcine olfactory (OEPC) and respiratory (REPC) primary cells were characterised against the nasal tumour cell line RPMI 265

With the advent of high throughput sequencing, the amount of genomic data available for animals (Metazoa) species has bloomed over the last decade, especially from transcriptomes due to lower sequencing costs and easier assembling process compared to genomes.Transcriptomic data sets have proven useful for phylogenomic studies, such as inference of

A few years after Kim Jong Un came Rugby - Shoes - Mens into office, North Korea is still attracting controversy in the headlines, and political sanctions are still in operation.Despite the harsh measures in place to isolate Pyongyang from sources of money and luxury, the rulers are able to get what they want using front companies or the help of ot

En esta contribución sobre la educación en Nicaragua pretendemos dar algunas impresiones sobre los cambios revolucionarios producidos en el sistema educativo y el papel que juega la llamada “Educación Popular”.Presentamos una corta descripción de los nuevos principios metodológicos, estructura organizativa y los grandes cambios producidos

High-performance computing (HPC) uses many Perfumes distributed computing resources to solve large computational science problems through parallel computation.Such an approach can reduce overall job execution time and increase the capacity of solving large-scale and complex problems.In the supercomputer, the job scheduler, the HPC’s flagship tool